Formulation and Assessment of Delayed/Slow-Release Diclofenac Sodium Edible Organogel Utilizing Low Molecular Weight Organogelators

Synthetically accessible, tunable, low-molecular-weight oligopeptide organogelators.

We report a synthetically simple approach to effective and tunable low molecular weight gelators based on amine-initiated oligomerisation of an amino acid N-carboxyanhydride.

Evaluation of Diclofenac Sodium Sustained Release Matrix Pellets: Impact of Polyethylene Glycols Molecular Weight.

Sustained release matrix pellets loaded with 5% w/w diclofenac sodium (DS) were prepared using extrusion/spheronization technique. Different polyethylene glycols (PEGs) of different molecular weight, namely PEG 2000, PEG 4000 and PEG 6000 were mixed with avicel PH 101® in different weight ratios to manufacture the pellet formulations and water was used as a binder. Mix torque rheomter was used ...

Formulation and Optimization of Sustained Release Tablets of Diclofenac Sodium Using Guar Gum as Release Modifier

PURPOSE OF STUDY: In the present study, an attempt was made to increase therapeutic effectiveness, reduction in dosing frequency and thus improving patient compliance, by developing sustained release matrix tablets of Diclofenac sodium using guar gum as release modifier. METHOD: Six batches of sustained release matrix tablets of Diclofenac sodium was prepared by using different drug: polymer ra...

Formulation and Evaluation of Diclofenac Sodium Sustained Release Tablets Using Melt Granulation Technique

Hydrophilic polymers alone are not quite efficient in controlling the release of highly water soluble drugs. Hydrophobic Polymer and pore forming agent have been extensively investigated for sustaining the release of drug. They provide several advantages include good stability at varying pH ranges and effectively retards the water soluble drug. In the present study it was a novel approach where...

formulation and physicochemical evaluation of sustained release diclofenac sodium ocular film